Author

M. R. Spalinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

G. Rogler· 3 shared A. N. Santos· 2 shared D. F. McCole· 2 shared M. L. Tremblay· 2 shared M. Scharl· 2 shared A. Hsiao· 1 shared A. Mookhoek· 1 shared A. Sayoc· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

G. Rogler

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Temperature-triggered in situ forming lipid mesophase gel for local treatment of ulcerative colitis

M. Carone, M. R. Spalinger, R. A. Gaultney, A. Mookhoek, P. Krebs, G. Rogler, P. Luciani, S. Aleandri

This study develops a temperature-triggered in situ forming lipid gel for topical treatment of ulcerative colitis, showing reduced inflammation in preclinical models.

bioRxiv · Sep 28, 2022Bioengineering

Co-cultivation is a powerful approach to produce a robust functionally designed synthetic consortium as a live biotherapeutic product (LBP)

F. Kurt, G. E. Leventhal, M. R. Spalinger, L. Anthamatten, P. Rogalla von Bieberstein, G. Rogler, C. Lacroix, T. de Wouters

This study designs a synthetic microbial consortium through co-cultivation and shows it is as effective as fecal microbiota transplants in treating colitis.

bioRxiv · Oct 13, 2021Microbiology

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

M. R. Spalinger, R. Hai, J. Li, A. N. Santos, T. M. Nordgren, M. L. Tremblay, L. Eckmann, E. Hanson, M. Scharl, X. Wu, B. S. Boland, D. F. McCole

The paper identifies a genetic variant that increases SARS-CoV-2 receptor expression and susceptibility, and shows a JAK inhibitor reduces this risk.

bioRxiv · Dec 9, 2020 · PreprintMicrobiology

The Autoimmune Susceptibility Gene, PTPN2, Restricts Expansion of a Novel Mouse Adherent-Invasive E. coli

A. Shawki, R. Alvarez, M. R. Spalinger, P. M. Ruegger, A. Sayoc, A. N. Santos, P. Chatterjee, J. Mitchell, J. Macbeth, M. L. Tremblay, A. Hsiao, J. Borneman, D. F. McCole

This study shows PTPN2 deficiency in mice promotes expansion of a novel adherent-invasive E. coli that worsens colitis.

bioRxiv · Jul 22, 2019Microbiology

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis

A. Wyss, T. Raselli, G. Schmelczer, G. Klinke, N. Perkins, M. Hersberger, M. R. Spalinger, K. Atrott, S. Lang, I. Frey-Wagner, M. Scharl, A. W. Sailer, O. Pabst, G. Rogler, B. Misselwitz

This study shows that the EBI2-7,25-dihydroxycholesterol axis is induced in colitis and promotes lymphoid structure accumulation during homeostasis and inflammation.

bioRxiv · Sep 24, 2018Immunology