17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats
Kimberly M. Holter, McKenna G. Klausner, Mary Hunter Hite, C. Moriarty, Samuel H. Barth, Bethany E. Pierce, Alexandria N Iannucci, Douglas J. Sheffler, Nicholas D. P. Cosford, Heather A. Bimonte‐Nelson, Kimberly F. Raab‐Graham, Robert W. Gould
This study shows that low estrogen in female rats increases sensitivity to NMDAR antagonists and reduces antipsychotic effectiveness, with GluN2A expression playing a key role.
Molecular Psychiatry · Apr 4, 2025Peer-reviewedAnimal Behavior & Cognition