Mutation of Ebola virus VP35 Ser129 uncouples interferon antagonist and replication functions
M. J. Morwitzer, A. Corona, L. Zinzula, E. Fanunza, C. Nigri, S. Distinto, C. Vornholt, V. Kumar, E. Tramontano, S. P. Reid
This study shows that phosphorylation of VP35 Ser129 modulates its functions, uncoupling interferon inhibition from replication, and identifies it as a potential therapeutic target.
bioRxiv · Aug 7, 2019 · PreprintMicrobiology