SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages
L. Shi, K. Kidder, Z. Bian, S. K. T. Chiang, C. Ouellette, Y. Liu
This study shows SIRPα enhances IL-4/13 signaling in macrophages by sequestering SHP-2, promoting alternative activation and immunosuppression.
bioRxiv · Aug 6, 2021Immunology