Tryptophan fluorescence quenching in β-lactam-interacting proteins is modulated by the structure of intermediates and final products of the acylation reaction
S. Triboulet, Z. Edoo, F. Compain, C. Ourghanlian, A. Dupuis, V. Dubee, L. Sutterlin, H. Atze, M. Etheve-Quelquejeu, J.-E. Hugonnet, M. Arthur
This study shows that fluorescence quenching in β-lactam-interacting proteins depends on the structure of reaction intermediates and products, not direct Trp-drug interactions.
bioRxiv · Jan 17, 2019Biochemistry