A small DNA virus initiates replication with no more than three genome copies per cell
R. Ren, L. Zheng, C. Perdoncini Carvalho, J. Han, S. Miyashita, D. Zhang, F. Qu
This study shows DNA viruses like TYLCV undergo intracellular population bottlenecks, limiting replication to no more than three genome copies per cell, ensuring lethal mutations are purged.
bioRxiv · May 27, 2022 · PreprintMicrobiology