HIV reverse transcriptase pre-steady-state kinetic analysis of chain terminators and translocation inhibitors reveals interactions between magnesium and nucleotide 3'-OH
C. R. Dilmore, J. J. DeStefano
This study analyzes HIV reverse transcriptase kinetics with various nucleotide analogs under different Mg2+ concentrations, showing that 3'-OH interactions with Mg2+ significantly affect incorporation rates and inhibition.
bioRxiv · Dec 21, 2020Biochemistry