Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency.
C. Ramos-Perez, M. Dominska, L. Anaissi-Afonso, S. Cazorla-Rivero, O. Quevedo, I. Lorenzo-Castrillejo, T. D. Petes, F. Machin
The paper investigates the effects of Top2 deficiency-induced mitotic catastrophe in budding yeast, finding that 75% of daughter cells become senescent and later decline in vitality with genomic imbalances.
bioRxiv · Nov 26, 2019Cell Biology