Virus-like particle delivery enables orthogonal genome editing in vitro and in vivo
Soochul Shin, Bae-Geun Nam, Eun Ji Park, Min Gu Kim, C. S. Cho, Yong-Woo Kim, Sang‐Yeon Lee, Jeong Hun Kim, Sangsu BAE
This paper introduces a method using virus-like particles to enable orthogonal genome editing by packaging distinct CRISPR effectors and gRNAs, allowing simultaneous gene editing without gRNA crosstalk in vitro and in vivo.
bioRxiv · Feb 11, 2026 · PreprintGenetics