A hold-and-feed mechanism drives directional DNA loop extrusion by condensin
I. A. Shaltiel, S. Datta, L. Lecomte, M. Hassler, M. Kschonsak, S. Bravo, C. Stober, S. Eustermann, C. H. Haering
This study reveals that condensin uses a hold-and-feed mechanism to extrude DNA loops bidirectionally by separating motor and anchor functions in distinct chambers.
bioRxiv · Oct 29, 2021Biochemistry