Author

M. Hassler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. Khvorova· 2 shared D. Echeverria· 2 shared A. Biscans· 1 shared A. Coles· 1 shared A. Summer· 1 shared B. Bramato· 1 shared B. Godinho· 1 shared C. Ferguson· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

A. Khvorova

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

K. Yamada, V. N. Hariharan, J. Caiazzi, R. Miller, C. Ferguson, E. Sapp, H. Fakih, Q. Tan, N. Yamada, R. Furgal, J. Paquette, B. Bramato, N. McHugh, A. Summer, C. Lochmann, , A. Khvorova

This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.

bioRxiv · May 26, 2023Biochemistry

A hold-and-feed mechanism drives directional DNA loop extrusion by condensin

I. A. Shaltiel, S. Datta, L. Lecomte, M. Hassler, M. Kschonsak, S. Bravo, C. Stober, S. Eustermann, C. H. Haering

This study reveals that condensin uses a hold-and-feed mechanism to extrude DNA loops bidirectionally by separating motor and anchor functions in distinct chambers.

bioRxiv · Oct 29, 2021Biochemistry

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

A. Biscans, A. Coles, R. Haraszti, D. Echeverria, M. Hassler, M. Osborn, A. Khvorova

This study develops lipophilic conjugates to enable siRNA delivery to extra-hepatic tissues, showing effective gene silencing in multiple organs.

bioRxiv · Mar 26, 2018Biochemistry