Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch Syndrome fibroblasts
C. T. Baez, E. Valencia, K. Velasquez, N. Ramirez, C. Guevara, A. Sandoval-Hernandez, C. Arboleda-Bustos, L. Olivos-Cisneros, G. Gutierrez-Ospina, H. Arboleda, G. Arboleda
This study examines WRS fibroblasts with POLR3A mutations, finding nucleolar disruption, P53 activation, and premature senescence.
bioRxiv · Jan 29, 2020Cell Biology