Author

C. Thirant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Bellini· 1 shared A. Costa· 1 shared A. Gauthier· 1 shared A. Grelier· 1 shared A. Kramdi· 1 shared A. M. Carcaboso· 1 shared A. Peltier· 1 shared A. Petit· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Bellini

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2 papers

Recent·Most cited

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity

C. Thirant, A. Peltier, S. Durand, A. Kramdi, C. Louis-Brennetot, C. Pierre-Eugene, A. Costa, A. Grelier, S. Zaidi, N. Gruel, I. Jimenez, E. Lapouble, G. Pierron, H. Brisse, A. Gauthier, , I. Janoueix-Lerosey

This study shows that neuroblastoma cells can switch between noradrenergic and mesenchymal identities through epigenetic reprogramming, influenced by both intrinsic factors and the microenvironment.

bioRxiv · Jan 7, 2021 · PreprintCancer Biology

Screening of clustered regulatory elements reveals functional cooperating dependencies in Leukemia.

S. Benbarche, C. K. Lopez, E. Salataj, C. Thirant, M.-C. Laiguillon, Z. Aid, S. Lecourt, M. Antonini, B. Pardieu, A. Petit, A. Puissant, J. Chaumeil, T. Mercher, C. Lobry

The paper identifies co-regulated genes in leukemia using CRISPRi screening of super-enhancer regions, showing that combined inhibition of KIT and PDGFRA synergizes to impair leukemia cell growth.

bioRxiv · Jun 24, 2019 · PreprintCancer Biology