Discovery and characterization of novel inhibitors against ALS-related SOD1(A4V) aggregation through screening of a chemical library using Differerential Scanning Fluorimetry (DSF)
M. Giannakou, D. Hatzinikolaou, C. Vorgias
This paper identifies compounds that affect SOD1(A4V) thermal stability using DSF, with some showing potential to stabilize or destabilize the protein.
bioRxiv · Dec 20, 2023 · PreprintBiochemistry