Effect of an amyloidogenic SARS-COV-2 protein fragment on α-synuclein monomers and fibrils
A. K. Jana, C. W. Lander, A. D. Chesney, U. H. E. Hansmann
This study uses molecular dynamics simulations to investigate how a SARS-CoV-2 protein fragment affects α-synuclein monomers and fibrils, finding it shifts the ensemble toward aggregation-prone conformations but has little effect on fibril stability.
bioRxiv · Feb 21, 2022 · PreprintBiophysics