U. H. E. Hansmann

SARS-COV-2 Spike Protein Fragment eases Amyloidogenesis of α-Synuclein

The paper shows that a specific SARS-COV-2 spike protein fragment promotes α-synuclein fibril formation over alternative structures using molecular dynamics simulations.

Human Amylin in the Presence of SARS-COV-2 Protein Fragments

The paper uses molecular dynamics simulations to study how SARS-COV-2 protein fragments affect amylin monomer-fibril equilibrium, comparing results with prior studies.

Effect of an amyloidogenic SARS-COV-2 protein fragment on α-synuclein monomers and fibrils

This study uses molecular dynamics simulations to investigate how a SARS-CoV-2 protein fragment affects α-synuclein monomers and fibrils, finding it shifts the ensemble toward aggregation-prone conformations but has little effect on fibril stability.

Presence of a SARS-COV-2 protein enhances Amyloid Formation of Serum Amyloid A

The paper uses molecular dynamics simulations to show that a SARS-COV-2 protein segment increases SAA amyloid formation through three mechanisms.

Effect of Lauric Acid on the Stability of Abeta-Oligomers

This study uses molecular dynamics simulations to show that lauric acid stabilizes A{beta} oligomers, with a stronger effect on barrel-shaped models than ring-like ones.

Altering the solubility of the antibiotic candidate Nisin - a computational study

This study uses molecular dynamics simulations to investigate how mutations affect nisin solubility and evaluates force fields' ability to model solubility of uncommon amino acids.

Stability of Human Serum Amyloid A Fibrils

This study uses molecular dynamics simulations to investigate factors affecting the stability of human SAA fibrils, identifying key structural features that influence their formation and stability.

Bifurcated Hydrogen Bonds and the Fold Switching of Lymphotactin

This study investigates the fold switching of lymphotactin, finding it proceeds through partially structured intermediates via bifurcated hydrogen bonds rather than requiring full unfolding.

Cleavage, down-regulation and aggregation of serum amyloid A

The paper uses molecular dynamics simulations to study how cleavage of SAA protein affects its down-regulation and aggregation potential, proposing a mechanism involving conformational switching and environmental conditions.

Large Fatty Acid-derived Aβ42 oligomers Form Ring-like Assemblies

This study determines the structures of large fatty acid-derived Aβ42 oligomers using molecular dynamics and biophysical methods, revealing ring-like assemblies with distinct sizes and functional properties.

The Effect of Retro-inverse D-Amino Acid Aβ-peptides on Aβ- Fibril Formation

This study investigates how DRI-Aβ peptides affect Aβ fibril formation and suggests they may enhance fibril formation while reducing toxic oligomers, indicating potential for Alzheimer's drug design.