Structural mechanism underpinning Thermus oshimai Pif1-mediated G-quadruplex unfolding
D. Yang-Xue, G. Hai-Lei, L. Na-Nv, C. Wei-Fei, S. Rety, X. XUGUANG
This study presents the first X-ray structure of Thermus oshimai Pif1 bound to a G-quadruplex, revealing how it recognizes and unfolds G4s through a distinct mechanism compared to DHX36.
bioRxiv · Aug 24, 2021Biophysics