Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
Fadi G. Alnaji, Mireille Farjo, Shu Ling Goh, Daryl Zheng Hao Aw, Paolo Alberto Lorenzini, Tongyu Liu, Rebekah Chan Lin-Zhen, C.A. Lee, Marco Vignuzzi, Christopher B. Brooke
This study analyzes influenza A virus deletion-containing genomes over time, finding that specific mutations enhance their replication and interference while being lethal in wild-type backgrounds.
Nature Communications · Jun 16, 2026Peer-reviewedMicrobiology