Pharmacokinetics and Efficacy of the FimH Inhibitor Sibofimloc in Preventing Necrotizing Enterocolitis in Preterm Piglets
Valeria Meléndez Hebib, Brooklynn Earls, Barbara Stoll, Caitlin Vonderohe, Gregory Guthrie, Henry J. Haiser, Martin Paton, Suresh Balani, Matthias Hesse, Douglas Burrin
This study evaluates the safety, pharmacokinetics, and efficacy of Sibofimloc, an FimH inhibitor, in preventing NEC in preterm piglets, finding no reduction in NEC incidence or severity despite reduced mucosal injury.
bioRxiv · Oct 13, 2026 · PreprintMicrobiology