The P3018S disease variant reveals how dynein's trailing motor sets ensemble velocity.
Arne Gennerich, Caitlyn Ann Walker, Lu Rao, Abhipsa Shatarupa, Xinglei Liu, Jun Yang, Hernando Sosa, Kai Zhang
The paper investigates how the P3018S mutation in dynein affects its function, revealing that the trailing motor in multi-dynein assemblies dictates ensemble velocity.
bioRxiv · May 18, 2026 · PreprintBiophysics