Modulation of pedunculopontine input to the basal ganglia relieves motor symptoms in Parkinsonian mice
Caixia Lin, Margreet C. Ridder, Jinhao Zhong, Eduardo A. Albornoz, Petra L. Sedlak, Li Xu, Trent M. Woodruff, Fangyi Chen, Pankaj Sah
This study identifies a neural circuit involving the pedunculopontine nucleus that modulates movement and gait in Parkinsonian mice, showing that targeting this circuit can alleviate motor symptoms.
bioRxiv · Mar 6, 2024 · PreprintNeuroscience