Author

Eduardo A. Albornoz

The University of QueenslandORCID 0000-0002-9976-6350Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 4 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Trent M. WoodruffiD· 5 shared Alberto Anastacio AmarillaiD· 2 shared Alejandro Rojas‐FernándeziD· 2 shared Alexander A. KhromykhiD· 2 shared Ariel IsaacsiD· 2 shared Benjamin LiangiD· 2 shared Daniel WattersoniD· 2 shared Ernst Jurgen WolvetangiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Trent M. WoodruffORCID

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Author profile →

5 papers

Recent·Most cited

Paraquat Licences α-Synuclein to Trigger NLRP3-Dependent Pyroptosis in Microglia

Yuzhihan Cao, Vandana Deora, Nemat Khan, Avril A. B. Robertson, Kate Schroder, Matthew A. Cooper, Trent M. Woodruff, Eduardo A. Albornoz

This study shows paraquat enables α-synuclein to trigger NLRP3-dependent pyroptosis in microglia, linking environmental toxins to Parkinson's disease pathogenesis.

bioRxiv · Jul 23, 2025 · PreprintNeuroscience

Interaction of Gut-Microbial Amyloids with Endogenous Amyloids can Drives Microglial Hyperactivity and Neuroinflammation in Alzheimers Disease

Helen Forgham, Eduardo A. Albornoz, Giovanni Pietrogrande, Jiayuan Zhu, Ka Hang Karen Chung, Muhammad S. Tahir, Syed Aoun Ali, Ruirui Qiao, Aleksandr Käkinen, Ernst Jurgen Wolvetang, Trent M. Woodruff, Julio Aguado, Daniel E. Otzen, Thomas Paul Davis, Ibrahim Javed

The paper shows microbial amyloids from gut pathogens can trigger microglial hyperactivity and neuroinflammation, contributing to Alzheimer's disease progression.

bioRxiv · Jan 15, 2025 · PreprintCell Biology

Modulation of pedunculopontine input to the basal ganglia relieves motor symptoms in Parkinsonian mice

Caixia Lin, Margreet C. Ridder, Jinhao Zhong, Eduardo A. Albornoz, Petra L. Sedlak, Li Xu, Trent M. Woodruff, Fangyi Chen, Pankaj Sah

This study identifies a neural circuit involving the pedunculopontine nucleus that modulates movement and gait in Parkinsonian mice, showing that targeting this circuit can alleviate motor symptoms.

bioRxiv · Mar 6, 2024 · PreprintNeuroscience

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

Julio Aguado, Alberto Anastacio Amarilla, Atefeh Taherian Fard, Eduardo A. Albornoz, Alexander Tyshkovskiy, Marius Schwabenland, Harman Kaur Chaggar, Naphak Modhiran, Cecilia Liliana Gomez Inclan, Ibrahim Javed, Alireza A. Baradar, Benjamin Liang, Lianli Peng, Malindrie Dharmaratne, Giovanni Pietrogrande, , Ernst Jurgen Wolvetang

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

Nature Aging · Nov 13, 2023Peer-reviewedNeuroscience

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction

Eduardo A. Albornoz, Alberto Anastacio Amarilla, Naphak Modhiran, Sandra E. Parker, Xaria X. Li, Danushka K. Wijesundara, Adriana C. Pliego Zamora, Christopher L. D. McMillan, Benjamin Liang, Nias Y. G. Peng, Julian D. J. Sng, Fatema Tuj Saima, Devina Paramitha, Rhys H. Parry, Michael Selorm Avumegah, , Trent M. Woodruff

This study shows SARS-CoV-2 activates microglial NLRP3 inflammasome via spike-ACE2 interaction, potentially linking viral infection to neurological symptoms like Parkinson's.

bioRxiv · Jan 11, 2022 · PreprintNeuroscience