Deoxyhypusine synthase is required for the translational regulation of pancreatic beta cell maturation
Craig T. Connors, Emily K. Anderson‐Baucum, Spencer R. Rosario, Catharina B.P. Villaca, Caleb D. Rutan, Paul Childress, Leah R. Padgett, Morgan A. Robertson, Teresa L. Mastracci
This study identifies DHPS/eIF5A as a gatekeeper of mRNA translation in pancreatic beta cells, showing its essential role in beta cell maturation and function, with DHPS deficiency leading to diabetes.
bioRxiv · Apr 24, 2023 · PreprintDevelopmental Biology