Author

Catharina B.P. Villaca

Indiana University – Purdue University IndianapolisORCID 0000-0001-7301-126XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Caleb D. Rutan· 1 shared Craig T. Connors· 1 shared Emily K. Anderson‐BaucumiD· 1 shared Fernanda OrtisiD· 1 shared Gustavo Jorge dos SantosiD· 1 shared Leah R. PadgettiD· 1 shared Morgan A. RobertsoniD· 1 shared Paul Childress· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperDevelopmental Biology

Caleb D. Rutan

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2 papers

Recent·Most cited

Cell BiologyIsletsPeer-reviewedSep 29, 2025

The effect of HNF4alpha knockout in beta cells is age and gender dependent

Catharina B.P. Villaca, Viviane R. Oliveira, Gustavo Jorge dos Santos, Fernanda Ortis

This study shows that HNF4alpha knockout in beta cells leads to age- and gender-dependent dysfunction, with males showing more severe ER stress and apoptosis than females.

2 citations

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintApr 24, 2023

Deoxyhypusine synthase is required for the translational regulation of pancreatic beta cell maturation

Craig T. Connors, Emily K. Anderson‐Baucum, Spencer R. Rosario…·Teresa L. Mastracci

This study identifies DHPS/eIF5A as a gatekeeper of mRNA translation in pancreatic beta cells, showing its essential role in beta cell maturation and function, with DHPS deficiency leading to diabetes.

1 citation

mouseexperimental assay

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