Oral administration of 1,10-phenanthroline-5-amine (PAA) significantly reduced amyloid plaque burden compared with untreated APP/PS1 mice.
Larry C. Schmued, Bryan Maloney, Calvert Schmued, Kaitlyn Gregerson, Debomoy K. Lahiri
This study validates that oral PAA reduces amyloid plaque burden in APP/PS1 mice and shows PAA directly binds to amyloid plaques in vitro.
bioRxiv · Jul 30, 2026 · PreprintNeuroscience