Enhanced Astrocyte Responses are Driven by a Genetic Risk Allele Associated with Multiple Sclerosis
Gerald D. Ponath, Matthew R. Lincoln, Maya Levine-Ritterman, Calvin Park, Somiah Dahlawi, Mayyan Mubarak, Tomokazu S. Sumida, Laura M. Airas, Shun Zhang, Cigdem Isitan, Thanh Duc Nguyen, Cedric S. Raine, David A. Hafler, David Pitt
The paper shows that the MS risk variant rs7665090G increases astrocyte NF-κB signaling and lymphocyte recruitment, leading to larger MS lesions.
Nature Communications · Dec 11, 2018Peer-reviewedNeuroscience