The proto-oncogene c-Src phosphorylates cGAS to reduce DNA binding and activation
William Dunker, Shivam A. Zaver, Cameron J. Howard, Joshua John Woodward
This study shows that c-Src phosphorylates cGAS, reducing its DNA binding and activation, thereby inhibiting anti-tumor immune responses in cancer.
bioRxiv · Oct 7, 2022 · PreprintMolecular Biology