Joshua John Woodward

Macrophage DYRK1A is broadly required for bacterial phagocytosis

This study identifies DYRK1A as a key host factor required for macrophage phagocytosis of Listeria monocytogenes and other bacteria.

BetaH proteolysis unleashes an electrostatic-homing antibacterial polymorphic toxin

This paper identifies and characterizes a diffusible polymorphic toxin system in Staphylococcus aureus that mediates inter-genus antagonism against Listeria monocytogenes through extracellular proteolysis and ABC transporter-mediated susceptibility.

Cyclic di-AMP inhibits Listeria monocytogenes thymineless death during infection

This study shows that cyclic di-AMP inhibits thymineless death in Listeria monocytogenes during infection, revealing a new regulatory mechanism for bacterial survival under thymidine starvation.

De novo design of high-affinity miniprotein binders targeting Francisella tularensis virulence factor

The paper designs high-affinity miniprotein binders targeting Flpp3, a virulence factor of Francisella tularensis, using physics-based and deep-learning methods, achieving sub-nanomolar affinities.

The proto-oncogene c-Src phosphorylates cGAS to reduce DNA binding and activation

This study shows that c-Src phosphorylates cGAS, reducing its DNA binding and activation, thereby inhibiting anti-tumor immune responses in cancer.

Thymidine starvation promotes c-di-AMP dependent inflammation during infection

This study shows that thymidine starvation in bacteria increases c-di-AMP, leading to STING activation and inflammation during infection.