Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004
Phoebe H. Fechtmeyer, Cameron Martinez, Johannes T.‐H. Yeh
This study characterizes the temporal and spatial dynamics of BTR2004-mediated degradation of BET family proteins using KLHL20, providing insights for future PROTAC design.
ACS Chemical Biology · Sep 2, 2025Peer-reviewedBiochemistry