From 2D to 4D: a Containerized Workflow and Browser to Explore Dynamic Chromatin Architecture
David Rogers, Cullen Roth, Cameron Tauxe, Jeannie T. Lee, Christina R. Steadman, Karissa Y. Sanbonmatsu, Anna Lappala, Shawn R. Starkenburg
The paper introduces 4DGBWorkflow and 4DGB, open-source tools that use molecular dynamics simulations constrained by Hi-C data to generate 3D chromatin reconstructions and integrate them with epigenomic data for visualization.
BMC Bioinformatics · Jan 8, 2026Peer-reviewedBioinformatics