Jeannie T. Lee

The paper determines the structural ensemble-to-function relations of the B2 SINE ribozyme using RNA chemical probing, X-ray scattering, and modeling, showing cleavage site dependency on its structure and function.

The paper introduces 4DGBWorkflow and 4DGB, open-source tools that use molecular dynamics simulations constrained by Hi-C data to generate 3D chromatin reconstructions and integrate them with epigenomic data for visualization.

This study shows Xist RNA binds ~100 autosomal genes beyond the inactive X chromosome, with Repeat B essential for its function, and identifies a small molecule inhibitor that disrupts this activity.

The paper investigates whether transposable elements (TEs) on the X chromosome undergo XCI or Xa-hyperactivation, finding TEs are only silenced during XCI and not activated during Xa-hyperactivation.

The paper describes the generation and characterization of patient-derived iPSC lines and isogenic pairs for Ogden syndrome, including CRISPR corrections and X-chromosome screening.

This paper re-analyzes CLAP data and finds PRC2 is an RNA binding protein, contradicting previous conclusions due to issues in the original analysis pipeline.

The paper shows that CTCF and BORIS work together in spermatogenesis, with their combined loss causing infertility due to defective meiosis and gene expression.

This study investigates how cohesin depletion or retention affects X-inactivation and chromosomal interactions, finding that cohesin balance is critical for proper Xi structure and gene silencing.

The paper investigates the role of megadomains and superloops in X chromosome inactivation, finding they are not required for silencing or gene escape.