Ptf1a robustly drives the gliogenic switch in the rodent embryonic cortex in a dosage-dependent manner by activating pro-glial gene expression programs
Haixiang Li, Kaiqin Lu, Xiaoxuan Wang, Can Jiao, Kang Huang, Shibo Xu, Yan Liu, She Chen, Shuijin He
This study shows that Ptf1a drives gliogenesis in rodent embryonic cortex by activating pro-glial gene programs, with dosage-dependent effects on oligodendrocyte production.
bioRxiv · Oct 14, 2025 · PreprintNeuroscience