Author

She Chen

Fudan UniversityORCID 0000-0002-4077-1649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Can Jiao· 1 shared Ge ZhangiD· 1 shared Guanxing PaniD· 1 shared Haixiang Li· 1 shared Haoxuan ZhongiD· 1 shared Hu HuiD· 1 shared Jianjun Zhang· 1 shared Jianzeng DongiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Can Jiao

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2 papers

Recent·Most cited

Ptf1a robustly drives the gliogenic switch in the rodent embryonic cortex in a dosage-dependent manner by activating pro-glial gene expression programs

Haixiang Li, Kaiqin Lu, Xiaoxuan Wang, Can Jiao, Kang Huang, Shibo Xu, Yan Liu, She Chen, Shuijin He

This study shows that Ptf1a drives gliogenesis in rodent embryonic cortex by activating pro-glial gene programs, with dosage-dependent effects on oligodendrocyte production.

bioRxiv · Oct 14, 2025 · PreprintNeuroscience

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease

Xiaowen Wu, Guanxing Pan, Lin Chang, Yulong Zhang, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi, Jianjun Zhang, Ruyi Xue, She Chen, Hu Hu, Jianzeng Dong, , Zhongren Ding

This study identifies TREM2 as a signaling hub linking ER stress, immune-inflammation, and platelet hyperactivity in CAD, showing that TREM2 downregulation exacerbates myocardial infarction and that TREM2-activating antibodies may offer therapeutic potential.

Journal of the American Heart Association · Jun 24, 2025Peer-reviewedPharmacology & Toxicology