SARS-CoV-2 RdRp uses NDPs as a substrate and is able to incorporate NHC into RNA from diphosphate form molnupiravir
Maofeng Wang, Cancan Wu, Nan Liu, Fengyu Zhang, Hongjie Dong, Shuai Wang, Min Chen, Xiaoqiong Jiang, Kundi Zhang, Lichuan Gu
This study shows SARS-CoV-2 RdRp can use NDPs and MDP to incorporate NHC into RNA, with MDP being a better substrate than MTP.
International Journal of Biological Macromolecules · Jan 1, 2023Peer-reviewedMolecular Biology