Author

Fengyu Zhang

Pennsylvania State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Alice CaiiD· 2 shared Gong CheniD· 2 shared Ju WangiD· 2 shared Lei ZhangiD· 2 shared Yuting BaiiD· 2 shared Zhenhua PaniD· 2 shared Zhouhai Zhu· 2 shared Zhuofan LeiiD· 2 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Alice CaiORCID

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Author profile →

6 papers

Recent·Most cited

FMR1 Perturbations Disrupt Sensory Corticostriatal Circuits and Mitochondrial Energetics in Fragile X Syndrome

Yu Yan, Dongyun Li, Jiangyu Yuan, Danyong Feng, Jiarui Chang, Fengyu Zhang, Man Xiong, Yan Jiang, Biao Yan, Qiong Xu, Rihui Li, Yi He, Peipei Liu, Mingshuo Shao, Minjie Shen

This study shows that FMR1 perturbations disrupt sensory corticostriatal circuits and mitochondrial function in FXS, with interventions improving social and cognitive deficits.

bioRxiv · Oct 11, 2026 · PreprintNeuroscience

Identification of the potential function-specific sites in subunits of vertebrate neuronal nicotinic acetylcholine receptors

Zhouhai Zhu, Fengyu Zhang, Ying Guan, Zhenhua Pan, Meng Li, Ju Wang

This study identifies function-specific sites in nAChR subunits using evolutionary analysis and spatial modeling, showing their roles in ligand binding and conformational changes.

bioRxiv · May 9, 2024 · PreprintBioinformatics

Analyzing the Involvement of Cholinesterases in the Immune Landscape of Lung Adenocarcinoma and Their Prognostic Values

Fengyu Zhang, Zhouhai Zhu, Ying Guan, Meng Li, Zhenhua Pan, Ju Wang

The paper identifies AChE and BChE as prognostic markers in LUAD, showing their association with immune landscape and prognosis in different patient subgroups.

bioRxiv · May 9, 2024 · PreprintMolecular Biology

SARS-CoV-2 RdRp uses NDPs as a substrate and is able to incorporate NHC into RNA from diphosphate form molnupiravir

Maofeng Wang, Cancan Wu, Nan Liu, Fengyu Zhang, Hongjie Dong, Shuai Wang, Min Chen, Xiaoqiong Jiang, Kundi Zhang, Lichuan Gu

This study shows SARS-CoV-2 RdRp can use NDPs and MDP to incorporate NHC into RNA, with MDP being a better substrate than MTP.

International Journal of Biological Macromolecules · Jan 1, 2023Peer-reviewedMolecular Biology

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

Brendan Puls, Yan Ping Ding, Fengyu Zhang, Mengjie Pan, Zhuofan Lei, Zifei Pei, Mei Hua Jiang, Yuting Bai, Cody Forsyth, Morgan Metzger, Tanvi Rana, Lei Zhang, Xiaoyun Ding, Matthew G. Keefe, Alice Cai, , Gong Chen

This study demonstrates efficient regeneration of dorsal spinal cord neurons from reactive astrocytes after injury using NeuroD1-mediated in vivo reprogramming via AAV.

Frontiers in Cell and Developmental Biology · Dec 16, 2020Peer-reviewedNeuroscience

Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

Lei Zhang, Zhuofan Lei, Ziyuan Guo, Zifei Pei, Yu‐Chen Chen, Fengyu Zhang, Alice Cai, Yung Kin Mok, Grace Lee, Vishal Swaminathan, Fan Wang, Yuting Bai, Gong Chen

This study converts reactive astrocytes into neurons in mice, reducing glial scar and restoring neural tissue by rebalancing neuron-glia ratios.

bioRxiv · Feb 7, 2018 · PreprintNeuroscience