Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Andy Cheuk‐Him Ng, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal A. Pileggi, Bojan Shutinoski, Juan Li, Angela Nguyen, Travis K. Fehr, Doo Soon Im, Steve M. Callaghan, , Michael G. Schlossmacher
This study shows that parkin reduces oxidative stress in mammalian brains by mediating H2O2 reduction and glutathione regeneration, but its absence leads to increased oxidative stress despite compensatory mechanisms.
bioRxiv · Apr 26, 2020 · PreprintNeuroscience