Author

Bojan Shutinoski

Ottawa Hospital Research InstituteORCID 0000-0003-4669-5656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Andy Cheuk‐Him NgiD· 2 shared Angela NguyeniD· 2 shared Arne HolmgreniD· 2 shared Daniel N. El KodsiiD· 2 shared David S. ParkiD· 2 shared Doo Soon ImiD· 2 shared Gary S. ShawiD· 2 shared Jacqueline M. Tokarew· 2 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Andy Cheuk‐Him NgORCID

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2 papers

Recent·Most cited

Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites

Jacqueline M. Tokarew, Daniel N. El Kodsi, Nathalie A. Lengacher, Travis K. Fehr, Angela Nguyen, Bojan Shutinoski, Brian O’Nuallain, Ming Jin, Jasmine M. Khan, Andy Cheuk‐Him Ng, Juan Li, Qiubo Jiang, Mei Zhang, Liqun Wang, Rajib Sengupta, , Michael G. Schlossmacher

This study investigates how parkin's redox state and insolubility in human midbrain relate to oxidative stress and dopamine metabolism, showing that parkin's cysteine modifications affect H2O2 levels and neuroprotection.

Acta Neuropathologica · Mar 10, 2021Peer-reviewedNeuroscience

Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain

Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Andy Cheuk‐Him Ng, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal A. Pileggi, Bojan Shutinoski, Juan Li, Angela Nguyen, Travis K. Fehr, Doo Soon Im, Steve M. Callaghan, , Michael G. Schlossmacher

This study shows that parkin reduces oxidative stress in mammalian brains by mediating H2O2 reduction and glutathione regeneration, but its absence leads to increased oxidative stress despite compensatory mechanisms.

bioRxiv · Apr 26, 2020 · PreprintNeuroscience