The Effects of Pressure and Temperature on the Thermodynamics of α-Helices.
George I. Makhatadze, Caitlyn Moustouka, Carleton Coffin, Franco O. Tzul
This study investigates how pressure and temperature affect α-helix stability using circular dichroism spectroscopy on model peptides, finding pressure stabilizes helices at low temperatures but destabilizes them at higher temperatures.
bioRxiv · Jan 29, 2025 · PreprintBiophysics