George I. Makhatadze

This study evaluates AI models for protein structure prediction by testing their ability to correctly place ionizable residues, finding they often bury these residues in non-polar regions despite physico-chemical principles.

The paper develops a FRET-based sensor using engineered fluorescent proteins to quantitatively detect amyloid fibrils, validated with PAPf39 fibrils.

This study investigates how pressure and temperature affect α-helix stability using circular dichroism spectroscopy on model peptides, finding pressure stabilizes helices at low temperatures but destabilizes them at higher temperatures.

The paper investigates how changes in electrostatic interactions drive proteome adaptation to high pressure in Colwellia, finding that some proteins become more stable while others maintain activity by counteracting pressure-induced rigidity.