Carlo Camilloni

This study elucidates the mechanism of gelsolin activation through a combination of experimental and computational methods, revealing a dynamic, domain-dependent process leading to a heterogeneous active-state ensemble.

This study evaluates multi-eGO's ability to predict PDZ2-peptide binding changes across mutations, showing good thermodynamic agreement but limited kinetic accuracy.

This paper uses molecular dynamics simulations to study how static electric fields affect Aβ42 fibrils, showing they destabilize fibrils by altering surface properties and reducing secondary nucleation.

This study investigates how ICA-105574, an HERG activator, shortens cardiac repolarization in severe LQT2 mutations through molecular mechanisms.

This study presents the first structural characterization of NFI-X, revealing its DNA-binding domain structure and key determinants for activity, providing a framework for understanding the NFI family's function and drug design.

The paper investigates the effects of four PNPT1 mutations on PNPase function in bacterial and human models, finding that mutation severity does not correlate with catalytic activity.

The paper identifies a missense mutation in HvCHLI causing reduced chlorophyll content in barley, which shows potential for breeding crops adapted to arid conditions.

This study identifies a conformational fingerprint distinguishing AL from MM light chains using SAXS and MD simulations, revealing a unique H state in AL LCs.

This study reveals how hnRNP A1 binds to the terminal loop of pri-mir-18a, destabilizing stem base-pairing to enhance miRNA processing.