PHAROS: turning single-cell perturbation models into target-directed drug-combination screens
Jon Bezney, Carlo Ruggeri, Federico Borra, Lei S. Qi, Francesca Meteora Buffa, Lars Michael Steinmetz
PHAROS uses a pretrained single-cell perturbation model to predict and prioritize effective drug combinations without retraining, showing success in cell lines and patient-derived tumors.
bioRxiv · Sep 10, 2026 · PreprintBioinformatics