Optineurin is a gatekeeper of mitochondrial health and proteostasis in Alzheimer's disease vulnerable neurons
Christina Tsagkogianni, Matteo Trivisonno, Johanna Sophie Willner, Carlos Garcia-Molinero, Yingyu Tang, Beatrice Mattina, María Latorre‐Leal, Wei Wang, Jean-Pierre Roussarie, Patricia Rodriguez‐Rodriguez
The paper identifies Optineurin as a key regulator of mitochondrial health and proteostasis in Alzheimer's disease vulnerable neurons, showing its downregulation leads to early dysfunction and neuronal loss.
bioRxiv · Mar 16, 2026 · PreprintNeuroscience