Author

María Latorre‐Leal

Karolinska InstitutetORCID 0000-0002-8434-3822Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Patricia Rodriguez‐RodrigueziD· 4 shared Julen GoikoleaiD· 3 shared Silvia MaioliiD· 3 shared Ángel Cedazo-Mı́ngueziD· 2 shared Francesca Eroli· 2 shared Jean-Pierre RoussarieiD· 2 shared Adamantia F. FragopoulouiD· 1 shared André FisahniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Patricia Rodriguez‐RodriguezORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Optineurin is a gatekeeper of mitochondrial health and proteostasis in Alzheimer's disease vulnerable neurons

Christina Tsagkogianni, Matteo Trivisonno, Johanna Sophie Willner, Carlos Garcia-Molinero, Yingyu Tang, Beatrice Mattina, María Latorre‐Leal, Wei Wang, Jean-Pierre Roussarie, Patricia Rodriguez‐Rodriguez

The paper identifies Optineurin as a key regulator of mitochondrial health and proteostasis in Alzheimer's disease vulnerable neurons, showing its downregulation leads to early dysfunction and neuronal loss.

bioRxiv · Mar 16, 2026 · PreprintNeuroscience

Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression.

Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez‐Rodriguez, Guillermo Vazquez Cabrera, Simona Laterza, María Latorre‐Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia F. Fragopoulou, André Fisahn, Luis Enrique Arroyo‐García

The paper investigates how microglia loss in the hippocampus contributes to early amyloid pathology progression by disrupting neural oscillations and synaptic function in a mouse model.

bioRxiv · Mar 14, 2024 · PreprintNeuroscience

Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities

Makrina Daniilidou, Francesca Eroli, Vilma Alanko, Julen Goikolea, María Latorre‐Leal, Patricia Rodriguez‐Rodriguez, William James Griffiths, Yuqin Wang, Manuela Pacciarini, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Anna Rosenberg, Nenad Bogdanović, Bengt G. Winblad, , Anna Matton

The paper identifies Alzheimer's disease biomarkers in a cohort without common comorbidities, finding associations between biomarkers and pathways like neuroinflammation and oxidative stress.

Brain Communications · Jan 1, 2023Peer-reviewedNeuroscience

Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia

Julen Goikolea, Jean-Pierre Roussarie, Gorka Gereñu, Raúl Loera‐Valencia, María Latorre‐Leal, Ángel Cedazo-Mı́nguez, Patricia Rodriguez‐Rodriguez, Silvia Maioli

This study identifies Trx80 as a neuron-derived peptide that modulates microglia interferon response via Trem2-dependent mechanisms in Alzheimer's disease models.

bioRxiv · Mar 9, 2022 · PreprintNeuroscience