Jean-Pierre Roussarie

This study creates a molecular atlas of the mouse entorhinal cortex using snRNAseq and compares it to macaque data, revealing conserved molecular patterns and gradients in neuron subtypes.

The paper identifies Optineurin as a key regulator of mitochondrial health and proteostasis in Alzheimer's disease vulnerable neurons, showing its downregulation leads to early dysfunction and neuronal loss.

This study profiles cell-type specific changes in human entorhinal cortex at early Alzheimer's disease stages, identifying dysregulation of Reelin signaling and downregulation of NPTX2 and CBLN4.

This study identifies astrocyte-derived extracellular matrix proteins, particularly SPARC, as regulators of synapse remodeling in stress-induced depression.

Seismic identifies cell-type-specific associations with complex traits by integrating scRNA-seq and GWAS, revealing trait-relevant cell groups and gene drivers.

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

The paper identifies region-specific astrocyte genes and pathways linked to Alzheimer's disease susceptibility using a network-guided approach and mouse gene expression data.

The paper identifies DEK as a driver of tau pathology in Alzheimer's disease vulnerable neurons using in silico modeling and experimental validation.

This study identifies Trx80 as a neuron-derived peptide that modulates microglia interferon response via Trem2-dependent mechanisms in Alzheimer's disease models.

The paper identifies translational and splicing differences in dopaminoceptive neurons and highlights PGE2's role in enhancing D2 dopamine receptor function in the dorsal striatum.

This study identifies a functional gene module associated with selective neuronal vulnerability in Alzheimer’s disease using integrated molecular and genetic data from mice and humans.