Peroxisome dysfunction alters metabolism of photoreceptor outer segments in human retinal pigment epithelium
Constantin Mouzaaber, Carly B. Feldman, Suzette M Huguenin, John Y.S. Han, Erin Trombly, Qitao Zhang, Aja M. Rieger, Hamed Hojjat, Brandon C. Huynh, Ehsan Misaghi, Alina Radziwon, Temesgen Fufa, Robert B. Hufnagel, Jason M. L. Miller, Matthew D. Benson
This study investigates how peroxisome dysfunction in human retinal pigment epithelium (RPE) affects photoreceptor outer segment metabolism, revealing disrupted fatty acid retroconversion and lipid droplet accumulation.
bioRxiv · Mar 8, 2026 · PreprintCell Biology