Temesgen Fufa

This study investigates how peroxisome dysfunction in human retinal pigment epithelium (RPE) affects photoreceptor outer segment metabolism, revealing disrupted fatty acid retroconversion and lipid droplet accumulation.

The paper maps transcriptional profiles in macaque retina and RPE-choroid tissues, identifying conserved gene expression patterns and signaling pathways relevant to high-acuity vision and disease.

The paper develops a method to integrate single cell transcriptome data from multiple retinal datasets across species to create a comprehensive ocular meta-atlas.

The paper optimizes a short-read de novo transcriptome pipeline using long-read data to identify novel gene isoforms in eye samples and their relevance to development and disease.

The paper integrates RNA-seq data from human eye tissues and other body tissues to identify biological processes and gene correlations, building gene networks and providing an interactive web tool.