Expansion microscopy reveals insulin granule clustering in human β-cells in type 2 diabetes
Licia Anna Pugliese, Valentina De Lorenzi, Gianmarco Ferri, Ha Vo, Allison Lindquist, Marta Tesi, Carmela De Luca, Mara Suleiman, Lorella Marselli, Yongxin Zhao, Piero Marchetti, Fabio Beltram, Francesco Cardarelli
This study uses expansion microscopy to analyze insulin granule organization in human β-cells, finding increased clustering in type 2 diabetes without significant granule depletion.
bioRxiv · May 8, 2026 · PreprintBiophysics