Lorella Marselli

This study maps spatial and functional states of human pancreatic cells in health and disease using combined single-cell and spatial transcriptomics with calcium imaging.

This study uses expansion microscopy to analyze insulin granule organization in human β-cells, finding increased clustering in type 2 diabetes without significant granule depletion.

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

The paper demonstrates that TOPMed imputation improves the identification of rare variants associated with type 2 diabetes in Latino populations, leading to novel associations and better polygenic scores.

The paper identifies hypermethylation of PNLIPRP1 in T2D patients and shows its association with acinar-to-ductal metaplasia and PDAC risk.

The paper identifies splicing QTLs in human pancreatic islets that contribute to type 2 diabetes susceptibility by affecting gene splicing and revealing novel molecular mechanisms.

The paper creates TIGER, a resource integrating RNA-seq and genotyping data from human pancreatic islets to identify eQTLs and their associations with type 2 diabetes.

The paper identifies stable reference genes for normalizing gene expression in human pancreatic beta cells under stress conditions using RNA-seq and qPCR validation.