APP family member dimeric complexes are formed predominantly in synaptic compartments
Sandra Schilling, Alexander August, Mathieu Meleux, Carolin Conradt, Luisa M Tremmel, Sandra Teigler, Virginie Adam, Ulrike Müller, Edward H. Koo, Stefan Kins, Simone Eggert
The paper investigates dimerization of APP family members in cultured cells and mouse brains, finding higher dimerization in brain tissue and enrichment in synaptic compartments, with reduced dimers in AD patients.
Cell & Bioscience · Aug 2, 2023Peer-reviewedNeuroscience