Ulrike Müller

CNTN4 modulates neural elongation through interplay with APP

This study identifies CNTN4's role in cortical development and shows its interaction with APP affects neural elongation and spine density.

APP family member dimeric complexes are formed predominantly in synaptic compartments

The paper investigates dimerization of APP family members in cultured cells and mouse brains, finding higher dimerization in brain tissue and enrichment in synaptic compartments, with reduced dimers in AD patients.

The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses

This study investigates the role of amyloid precursor protein (APP) in synaptic transmission at medial perforant path synapses using organotypic cultures and finds that presynaptic APP affects neurotransmission efficacy.

Choroid plexus APP regulates adult brain proliferation and animal behavior

This study shows that choroid plexus APP affects adult brain proliferation and behavior in mice, with reduced proliferation and cognitive deficits observed after APP overexpression.

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.

Amyloid-beta mediates homeostatic synaptic plasticity

This study shows that amyloid-beta, not APP or its secreted fragments, mediates homeostatic synaptic plasticity in the absence of APP.

Single cell 3'UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism

The paper analyzes 3'UTR changes during neuronal differentiation and in ASD, finding longer 3UTRs in ASD patients and a role for CPEB4 and APLP1 in APA regulation.

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

This study shows that presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity, linking APP processing to synaptic function in Alzheimer's disease.